First, let’s have a quick intro on the framework. The project was originally created to make a version of Firefox that was able to run solely from a USB thumb drive. It required a computer that was running Windows®, but it did not need Firefox. The thumb drive carried the application and stored all the history, bookmarks, and settings back onto the thumb drive. This setup allows privacy, secrecy, and convenience. Today, the PortableApps.com framework allows for a ton more applications to be run in a portable configuration.
To use the framework, you simply download the installer from the PortableApps.com website. Run the installer and point it to your thumb drive. This installs the framework, but no applications. Here is what the application launcher looks like.